DescriptionNew computational opportunities and challenges have emerged within the cancer research and clinical application areas as the size, number, variety and complexity of cancer datasets have grown in recent years. Simultaneously, advances in computational capabilities have grown and are expected to continue to reach unprecedented scales. Such opportunities to impact cancer computationally are underscored in the 2016 Cancer Moonshot Blue Ribbon Panel Report. The workshop focuses on bringing together interested individuals ranging from clinicians, mathematicians, data scientists, computational scientists, hardware experts, engineers, developers, leaders and others with an interest in advancing the use of computation at all levels to better understand, diagnose, treat and prevent cancer. With an interdisciplinary focus, the workshop provides opportunities for participants to learn how computation is employed across multiple areas including imaging, genomics, analytics, modeling, pathology and drug discovery with a focus on impacting cancer. As an interdisciplinary workshop, the cross-disciplinary sharing of insight and challenges fosters collaborations and future innovations to accelerate the progress in computationally and data driven cancer research and clinical applications. The forward focus of the workshop looks at challenges and opportunities for large scale HPC, including exascale applications involving cancer.