DescriptionTraditionally, there has been a division of labor between computers and humans where all forms of number crunching and bit manipulation are left to computers, whereas intelligent decision-making is left to us humans. We are now at the cusp of a major transformation that can disrupt this balance. This disruption is triggered by an unprecedented convergence of massive compute with massive data, and some recent algorithmic advances. This confluence has the potential to spur a virtuous cycle of compute. It can significantly impact how we do computing and what computing can do for us. In this talk, I will discuss some of the application-level opportunities and system-level challenges that lie at the heart of this intersection of traditional high-performance computing with emerging data-intensive computing.