DescriptionHigh-performance computing has long been employed in cancer research and clinical applications. Ongoing challenges of deriving insight from increasing amounts of cancer related information have accelerated the significance of HPC and collaborations in cancer research, in areas including simulations, data analytics and deep learning. Underscored by several recent high-profile efforts, communities are rapidly developing where HPC is applied to cancer challenges. This SC17 BoF provides an important venue, bringing these communities together around a common theme of HPC and cancer. Following the successful format of past years, the BoF will be informative and highly-interactive with presentations and significant attendee discussion.